Hemostasis, Thrombosis, and Vascular Biology

نویسندگان

  • Amir Tadros
  • David P. Hughes
  • Benjamin J. Dunmore
  • Nicholas P. J. Brindle
چکیده

A20 binding inhibitor of NFB activation-2, ABIN-2, is a newly identified intracellular protein that interacts with the zinc finger protein A20. ABIN-2 inhibits nuclear factor– B (NFB) activity and is a possible effector of A20 regulation of NFB. Although A20 is a potent inhibitor of endothelial apoptosis, the effect of ABIN-2 on apoptosis is not known. ABIN-2 also interacts with the endothelial receptor Tie2. This receptor is essential for blood vessel formation and promotes endothelial survival. Here we examine the effects of ABIN-2 on endothelial cell apoptosis and its potential involvement in Tie2mediated endothelial survival. ABIN-2 was found to inhibit endothelial apoptosis and rescue cells from death following growth factor deprivation. The inhibitors of phosphatidylinositol-3 kinase, wortmannin and LY294002, suppressed ABIN-2 inhibition of endothelial cell death. Deletion of the carboxy-terminus of ABIN-2 removed its ability to inhibit apoptosis. Expression of truncated ABIN-2 prevented the Tie2activating ligand angiopoietin-1 from inhibiting endothelial cell death. (Blood. 2003;102:4407-4409)

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparison of Celox powder and conventional dressing on hemostasis of vascular access site in hemodialysis patients

Background: Common measures to stop bleeding can run the risk of clotting and thrombosis due to prolonged application of pressure. Topical homeostatic agents have an important role in decreasing time to hemostasis and consequently prevention of the complications.   Aim: the aim of this study was to compare Celox powder and conventional bandage on time to hemostasis in the vascular access site i...

متن کامل

Intelligent platelet inhibitors are on the horizon.

Hemostasis is a tightly regulated physiological sequence of events that maintains vascular integrity and imminent blood loss after vessel injury. Platelets play a critical role in primary hemostasis and in regulation of coagulation. Under physiological conditions, hemostasis and thrombosis are in a fragile equilibrium. Uncontrolled platelet activation leads to intravascular thrombosis and organ...

متن کامل

Intrinsic pathway of coagulation and arterial thrombosis.

Formation of a fibrin clot is mediated by a group of tightly regulated plasma proteases and cofactors. While this system is essential for minimizing blood loss from an injured blood vessel (hemostasis), it also contributes to pathologic fibrin formation and platelet activation that may occlude vessels (thrombosis). Many antithrombotic drugs target key elements of the plasma coagulation mechanis...

متن کامل

Role of tissue factor in hemostasis, thrombosis, and vascular development.

Tissue factor (TF) is best known as the primary cellular initiator of blood coagulation. After vessel injury, the TF:FVIIa complex activates the coagulation protease cascade, which leads to fibrin deposition and activation of platelets. TF deficiency causes embryonic lethality in the mouse and there have been no reports of TF deficiency in humans. These results indicate that TF is essential for...

متن کامل

Computational approaches to studying thrombus development.

In addition to descriptive biological models, many computational models have been developed for hemostasis/thrombosis that provide quantitative characterization of thrombus development. Simulations using computational models that have been developed for coagulation reactions, platelet activation, and fibrinogen assembly have been shown to be in close agreement with experimental data. Models of ...

متن کامل

Minimal functional model of hemostasis in a biomimetic microfluidic system.

Biology is functional, and this function both inspires and puzzles. Inspiration from biology has led to the development of biomimetic systems—artificial systems that function by mimicking biology. Biomimetic systems have been successfully created in self-assembly, 2] materials, chemical synthesis, and surface chemistry. They often provide insight into the puzzles of biology, because to develop ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2003